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A 582941
CAS No. 848591-90-2
A 582941 ( —— )
Catalog No. M22382 CAS No. 848591-90-2
A 582941 is a Selective agonist of α7 nAChR partialA-582941 was found to exhibit high-affinity binding and partial agonism at alpha7 nAChRs.?In vitro and in vivo studies indicated that A-582941 activates signaling pathways known to be involved in cognitive function such as ERK1/2 and CREB phosphorylation.?
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 87 | Get Quote |
|
| 10MG | 147 | Get Quote |
|
| 25MG | 327 | Get Quote |
|
| 50MG | 489 | Get Quote |
|
| 100MG | 705 | Get Quote |
|
| 500MG | 1458 | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameA 582941
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NoteResearch use only, not for human use.
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Brief DescriptionA 582941 is a Selective agonist of α7 nAChR partialA-582941 was found to exhibit high-affinity binding and partial agonism at alpha7 nAChRs.?In vitro and in vivo studies indicated that A-582941 activates signaling pathways known to be involved in cognitive function such as ERK1/2 and CREB phosphorylation.?
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DescriptionA 582941 is a Selective agonist of α7 nAChR partialA-582941 was found to exhibit high-affinity binding and partial agonism at alpha7 nAChRs.?In vitro and in vivo studies indicated that A-582941 activates signaling pathways known to be involved in cognitive function such as ERK1/2 and CREB phosphorylation.?A-582941 enhanced cognitive performance in behavioral models that capture domains of working memory, short-term recognition memory, memory consolidation, and sensory gating deficit.?A-582941 exhibited a benign secondary pharmacodynamic and tolerability profile as assessed in a battery of assays of cardiovascular, gastrointestinal, and CNS function.
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Synonyms——
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PathwayEndocrinology/Hormones
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TargetAChR
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Recptorα7 nAChR
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Research Area——
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Indication——
Chemical Information
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CAS Number848591-90-2
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Formula Weight280.37
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Molecular FormulaC17H20N4?
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Purity>98% (HPLC)
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Solubility——
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SMILES[H][C@@]12CN(C)C[C@]1([H])CN(C2)c1ccc(nn1)-c1ccccc1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Tietje K R , Anderson D J , Bitner R S , et al. Preclinical Characterization of A‐582941: A Novel α7 Neuronal Nicotinic Receptor Agonist with Broad Spectrum Cognition‐Enhancing Properties[J]. Cns Neuroence & Therapeutics, 2010, 14(1):65-82.
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